Impurity of Stem Cell Graft by Murine Embryonic Fibroblasts – Implications for Cell-Based Therapy of the Central Nervous System
Identifieur interne : 000A38 ( Main/Exploration ); précédent : 000A37; suivant : 000A39Impurity of Stem Cell Graft by Murine Embryonic Fibroblasts – Implications for Cell-Based Therapy of the Central Nervous System
Auteurs : Marek Molcanyi [Allemagne] ; Narges Zare Mehrjardi [Allemagne] ; Ute Sch Fer [Autriche] ; Nadia Nabil Haj-Yasein [Norvège] ; Michael Brockmann [Allemagne] ; Marina Penner [Allemagne] ; Peter Riess [Allemagne] ; Clemens Reinshagen [États-Unis] ; Bernhard Rieger [Allemagne] ; Tobias Hannes [Allemagne] ; Jürgen Hescheler [Allemagne] ; Bert Bosche [Canada, Allemagne]Source :
- Frontiers in Cellular Neuroscience [ 1662-5102 ] ; 2014.
Abstract
Stem cells have been demonstrated to possess a therapeutic potential in experimental models of various central nervous system disorders, including stroke. The types of implanted cells appear to play a crucial role. Previously, groups of the stem cell network NRW implemented a feeder-based cell line within the scope of their projects, examining the implantation of stem cells after ischemic stroke and traumatic brain injury. Retrospective evaluation indicated the presence of spindle-shaped cells in several grafts implanted in injured animals, which indicated potential contamination by co-cultured feeder cells (murine embryonic fibroblasts – MEFs). Because feeder-based cell lines have been previously exposed to a justified criticism with regard to contamination by animal glycans, we aimed to evaluate the effects of stem cell/MEF co-transplantation. MEFs accounted for 5.3 ± 2.8% of all cells in the primary FACS-evaluated co-culture. Depending on the culture conditions and subsequent purification procedure, the MEF-fraction ranged from 0.9 to 9.9% of the cell suspensions
Url:
DOI: 10.3389/fncel.2014.00257
PubMed: 25249934
PubMed Central: 4155790
Affiliations:
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sortKey="Molcanyi, Marek" sort="Molcanyi, Marek" uniqKey="Molcanyi M" first="Marek" last="Molcanyi">Marek Molcanyi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neurophysiology, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Clinic of Neurosurgery, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mehrjardi, Narges Zare" sort="Mehrjardi, Narges Zare" uniqKey="Mehrjardi N" first="Narges Zare" last="Mehrjardi">Narges Zare Mehrjardi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neurophysiology, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sch Fer, Ute" sort="Sch Fer, Ute" uniqKey="Sch Fer U" first="Ute" last="Sch Fer">Ute Sch Fer</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Research Unit for Experimental Neurotraumatology, Medical University of Graz</institution>,<addr-line>Graz</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haj Yasein, Nadia Nabil" sort="Haj Yasein, Nadia Nabil" uniqKey="Haj Yasein N" first="Nadia Nabil" last="Haj-Yasein">Nadia Nabil Haj-Yasein</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo</institution>,<addr-line>Oslo</addr-line>,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brockmann, Michael" sort="Brockmann, Michael" uniqKey="Brockmann M" first="Michael" last="Brockmann">Michael Brockmann</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Pathology, Kliniken der Stadt Köln, Cologne-Merheim Hospital, University of Witten/Herdecke</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Penner, Marina" sort="Penner, Marina" uniqKey="Penner M" first="Marina" last="Penner">Marina Penner</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Clinic of Neurosurgery, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Riess, Peter" sort="Riess, Peter" uniqKey="Riess P" first="Peter" last="Riess">Peter Riess</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Traumatology and Orthopedics, HELIOS Klinik Bad Berleburg</institution>,<addr-line>Bad Berleburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reinshagen, Clemens" sort="Reinshagen, Clemens" uniqKey="Reinshagen C" first="Clemens" last="Reinshagen">Clemens Reinshagen</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Molecular Neurotherapy and Imaging Laboratory, Massachusetts General Hospital, Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Radiology, Massachusetts General Hospital, Harvard Medical School</institution>,<addr-line>Boston, MA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rieger, Bernhard" sort="Rieger, Bernhard" uniqKey="Rieger B" first="Bernhard" last="Rieger">Bernhard Rieger</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Clinic of Neurosurgery, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hannes, Tobias" sort="Hannes, Tobias" uniqKey="Hannes T" first="Tobias" last="Hannes">Tobias Hannes</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neurophysiology, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Pediatric Cardiology, Heart Center Cologne, Medical Faculty, University Hospital of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hescheler, Jurgen" sort="Hescheler, Jurgen" uniqKey="Hescheler J" first="Jürgen" last="Hescheler">Jürgen Hescheler</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Neurophysiology, Medical Faculty, University of Cologne</institution>,<addr-line>Cologne</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bosche, Bert" sort="Bosche, Bert" uniqKey="Bosche B" first="Bert" last="Bosche">Bert Bosche</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Neurosurgery, St Michael’s Hospital, Keenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Department of Surgery, University of Toronto</institution>,<addr-line>Toronto, ON</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Neurology, University Hospital of Essen, University of Duisburg-Essen</institution>,<addr-line>Essen</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Cellular Neuroscience</title><idno type="eISSN">1662-5102</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Stem cells have been demonstrated to possess a therapeutic potential in experimental models of various central nervous system disorders, including stroke. The types of implanted cells appear to play a crucial role. Previously, groups of the stem cell network NRW implemented a feeder-based cell line within the scope of their projects, examining the implantation of stem cells after ischemic stroke and traumatic brain injury. Retrospective evaluation indicated the presence of spindle-shaped cells in several grafts implanted in injured animals, which indicated potential contamination by co-cultured feeder cells (murine embryonic fibroblasts – MEFs). Because feeder-based cell lines have been previously exposed to a justified criticism with regard to contamination by animal glycans, we aimed to evaluate the effects of stem cell/MEF co-transplantation. MEFs accounted for 5.3 ± 2.8% of all cells in the primary FACS-evaluated co-culture. Depending on the culture conditions and subsequent purification procedure, the MEF-fraction ranged from 0.9 to 9.9% of the cell suspensions <italic>in vitro</italic>. MEF survival and related formation of extracellular substances <italic>in vivo</italic> were observed after implantation into the uninjured rat brain. Impurity of the stem cell graft by MEFs interferes with translational strategies, which represents a threat to the potential recipient and may affect the graft microenvironment. The implications of these findings are critically discussed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arnhold, S" uniqKey="Arnhold S">S. Arnhold</name></author><author><name sortKey="Lenartz, D" uniqKey="Lenartz D">D. Lenartz</name></author><author><name sortKey="Kruttwig, K" uniqKey="Kruttwig K">K. Kruttwig</name></author><author><name sortKey="Klinz, F J" uniqKey="Klinz F">F. J. Klinz</name></author><author><name sortKey="Kolossov, E" uniqKey="Kolossov E">E. Kolossov</name></author><author><name sortKey="Hescheler, J" uniqKey="Hescheler J">J. 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Joussen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>Norvège</li><li>États-Unis</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Molcanyi, Marek" sort="Molcanyi, Marek" uniqKey="Molcanyi M" first="Marek" last="Molcanyi">Marek Molcanyi</name></noRegion><name sortKey="Bosche, Bert" sort="Bosche, Bert" uniqKey="Bosche B" first="Bert" last="Bosche">Bert Bosche</name><name sortKey="Brockmann, Michael" sort="Brockmann, Michael" uniqKey="Brockmann M" first="Michael" last="Brockmann">Michael Brockmann</name><name sortKey="Hannes, Tobias" sort="Hannes, Tobias" uniqKey="Hannes T" first="Tobias" last="Hannes">Tobias Hannes</name><name sortKey="Hannes, Tobias" sort="Hannes, Tobias" uniqKey="Hannes T" first="Tobias" last="Hannes">Tobias Hannes</name><name sortKey="Hescheler, Jurgen" sort="Hescheler, Jurgen" uniqKey="Hescheler J" first="Jürgen" last="Hescheler">Jürgen Hescheler</name><name sortKey="Mehrjardi, Narges Zare" sort="Mehrjardi, Narges Zare" uniqKey="Mehrjardi N" first="Narges Zare" last="Mehrjardi">Narges Zare Mehrjardi</name><name sortKey="Molcanyi, Marek" sort="Molcanyi, Marek" uniqKey="Molcanyi M" first="Marek" last="Molcanyi">Marek Molcanyi</name><name sortKey="Penner, Marina" sort="Penner, Marina" uniqKey="Penner M" first="Marina" last="Penner">Marina Penner</name><name sortKey="Rieger, Bernhard" sort="Rieger, Bernhard" uniqKey="Rieger B" first="Bernhard" last="Rieger">Bernhard Rieger</name><name sortKey="Riess, Peter" sort="Riess, Peter" uniqKey="Riess P" first="Peter" last="Riess">Peter Riess</name></country><country name="Autriche"><noRegion><name sortKey="Sch Fer, Ute" sort="Sch Fer, Ute" uniqKey="Sch Fer U" first="Ute" last="Sch Fer">Ute Sch Fer</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Haj Yasein, Nadia Nabil" sort="Haj Yasein, Nadia Nabil" uniqKey="Haj Yasein N" first="Nadia Nabil" last="Haj-Yasein">Nadia Nabil Haj-Yasein</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Reinshagen, Clemens" sort="Reinshagen, Clemens" uniqKey="Reinshagen C" first="Clemens" last="Reinshagen">Clemens Reinshagen</name></noRegion><name sortKey="Reinshagen, Clemens" sort="Reinshagen, Clemens" uniqKey="Reinshagen C" first="Clemens" last="Reinshagen">Clemens Reinshagen</name></country><country name="Canada"><noRegion><name sortKey="Bosche, Bert" sort="Bosche, Bert" uniqKey="Bosche B" first="Bert" last="Bosche">Bert Bosche</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25249934" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |